Brief Explanation

Nanofibers are defined as cylindrical structures with an outer diameter of less than 1,000 nm and an aspect ratio (ratio between length and width) greater than 50. Microfibers are also cylindrical structures with an outer diameter of over 1,000 nm.

Fibers are used extensively in many important science and engineering research areas, including purification, filtration, tissue engineering, regenerative medicine, wound healing, drug delivery systems, sensor, energy, and cosmetics. Electrospinning is the most widely used method for fiber production in the market.

As MecNano Technologies, we use the pressurized gyration technique in fiber production. The pressurized rotation technique is a production technique based on centrifugal force, which enables the production of size-adjustable fiber with high efficiency.

As MecNano Technologies, we produce polymeric microfiber and nanofiber.

Unique Features

• Controlled drug release
• Highly active pharmaceutical ingredient encapsulation
• Enhanced mechanical strength
• Improving cellular activities such as cell attachment, proliferation, and differentiation
• Mimic the natural structure of the extracellular matrix
• Ability to specifically functionalize its surface
• High surface area/volume ratio
• High nanoporosity

Our Polymeric Micro/nanofibers

Our micro/nanofibers are produced by using water-soluble and non-water-soluble polymers alone or as composites. Micro/nanoparticles can be loaded in micro/nanofibers without drug release from particles.

• Polycaprolactone (PCL)
• Polylactic acid (PLA)
• Polyvinyl alcohol (PVA)
• Polyethylene oxide (PEO)
• Polyvinyl pyrrolidone (PVP)

Our Articles with Polymeric Micro/nanofibers

1. Guler E., Nur Hazar-Yavuz A., Tatar E., Morid Haidari M., Sinemcan Ozcan G., Duruksu G., Graça M. P. F., Kalaskar D. M., Gündüz O., Cam M. E. Oral empagliflozin-loaded tri-layer core-sheath fibers fabricated using tri-axial electrospinning: Enhanced in vitro and in vivo antidiabetic performance.

International Journal of Pharmaceutics, cilt.635, ss.122716, 2023 (SCI-Expanded, Etki değeri: 6.510)

2.  Babazade R., Ertas B., Sinemcan Ozcan G., Kiyak Kirmaci H., Tatar E., Taskin T., Yazir Y., Cam M. E. Synergistic anticancer effects of metformin and Achillea vermicularis Trin-loaded nanofibers on human pancreatic cancer cell line: An in vitro study. European Polymer Journal, cilt.179, 2022 (SCI-Expanded, Etki değeri: 5.546)

3. Topal F., Ertaş B., Guler E., Gurbuz F., Ozcan G. S., Aydemir O., Böcekçi V. G., Duruksu G., Şahin Çam C., Yazır Y., Cam M. E. A novel multi-target strategy for Alzheimer’s disease treatment via sublingual route: Donepezil/memantine/curcumin-loaded nanofibers. Biomaterials Advances, cilt.138, 2022 (SCI-Expanded, Etki değeri: 8.457)

4. Aydin S., Kabaoglu I., Guler E., Topal F., Yavuz A. N., Ekentok Atıcı C., Tatar E., Gurbuz F., Gündüz O., Cam M. E. A Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin-Loaded Polycaprolactone/Polylactic Acid Nanofibers. Macromolecular Materials and Engineering, cilt.307, sa.5, 2022 (SCI-Expanded, Etki değeri: 4.367)

5. Alenezi H., Cam M. E., Edirisinghe M. Core-sheath polymer nanofiber formation by the simultaneous application of rotation and pressure in a novel purpose-designed vessel. Applied Physics Reviews, cilt.8, sa.4, 2021 (SCI-Expanded, Etki değeri: 19.527)

6. Alfares F. S., Guler E., Alenezi H., Cam M. E., Edirisinghe M. Optimization of Process-Control Parameters for the Diameter of Electrospun Hydrophilic Polymeric Composite Nanofibers. Macromolecular Materials and Engineering, cilt.306, sa.12, 2021 (SCI-Expanded, Etki değeri: 4.367)

7. Guler E., Baripoglu Y. E., Alenezi H., Arikan A., Babazade R., Unal S., Duruksu G., Alfares F. S., Yazir Y., Oktar F. N., Gunduz O., Cam M. E.  Vitamin D3/vitamin K2/magnesium-loaded polylactic acid/tricalcium phosphate/polycaprolactone composite nanofibers demonstrated osteoinductive effect by increasing Runx2 via Wnt/β-catenin pathway. International Journal of Biological Macromolecules, cilt.190, ss.244-258, 2021 (SCI-Expanded, Etki değeri: 8.025)

8. Mohamady Hussein M. A., Guler E., Rayaman E., Cam M. E., Şahin A., Grinholc M., Sezgin Mansuroglu D., Sahin Y. M., Gündüz O., Muhammed M. Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers. Carbohydrate Polymers, cilt.270, 2021 (SCI-Expanded, Etki değeri: 10.723)

9. Cam M. E., Ertaş B., Alenezi H., Hazar-Yavuz A. N., Cesur S., Ozcan G. S., Ekentok C., Guler E., Katsakouli C., Demirbas Z., Ediresinghe M. Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study. Materials Science & Engineering C, cilt.119, 2021 (SCI-Expanded, Etki değeri: 7.328)

10. Cam M. E., Hazar-Yavuz A. N., Cesur S., Ozkan O., Alenezi H., Turkoglu Sasmazel H., Sayip Eroglu M., Brako F., Ahmed J., Kabasakal L., Ediresinghe M. A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches. International Journal of Pharmaceutics, cilt.588, 2020 (SCI-Expanded, Etki değeri: 6.510)

11. Cam M. E., Crabbe-Mann M., Alenezi H., Hazar-Yavuz A. N., Ertas B., Ekentok C., Ozcan G. S., Topal F., Guler E., Yazir Y., Ediresinghe M. The comparision of glybenclamide and metformin-loaded bacterial cellulose/gelatin nanofibres produced by a portable electrohydrodynamic gun for diabetic wound healing. European Polymer Journal, cilt.134, 2020 (SCI-Expanded, Etki değeri: 5.546)

12. Cam M. E., Yildiz S., Alenezi H., Cesur S., Ozcan G., Erdemir G., Edirisinghe U., Akakin D., Kuruca D., Kabasakal L., Ediresinghe M. Evaluation of burst release and sustained release of pioglitazone-loaded fibrous mats on diabetic wound healing: an in vitro and in vivo comparison study. Journal of The Royal Socıety Interface, cilt.17, sa.162, 2020 (SCI-Expanded, Etki değeri: 4.293)

13. Alenezi H., Cam M. E., Edirisinghe M. Experimental and theoretical investigation of the fluid behavior during polymeric fiber formation with and without pressure Applied Physics Reviews, cilt.6, sa.4, 2019 (SCI-Expanded, Etki değeri: 19. 527)

14. Cam M. E., Cesur S., Taşkın T., Erdemir G., Kuruca D. S., Sahin Y. M., Kabasakal L., Gunduz O. Fabrication, characterization and fibroblast proliferative activity of electrospun Achillea lycaonica-loaded nanofibrous mats. European Polymer Journal, cilt.120, 2019 (SCI-Expanded, Etki değeri: 5.546)