Man at the plastic surgeon

Micro/nanoparticle

Brief Explanation

Nanoparticles are spherical particles composed of natural or artificial materials. Their sizes range from 1 to 100 nm. As a result of their spherical shape and high surface area/volume ratio, these particles have a wide variety of potential applications. Those with dimensions over 100 nm are defined as microparticles. Particle technology is advancing rapidly, providing new and effective treatments for a variety of diseases, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. However, targeting drugs effectively and locally to the brain remains a challenge due to the restrictive properties of the blood-brain barrier. Various strategies have been developed to overcome this. Particles are used extensively in many important science and engineering research fields, including medicine and healthcare, manufacturing and materials engineering, environmental engineering, electronics, energy storage, and mechanical industry. As MecNano Technologies, we produce various organic microparticles and nanoparticles.

Unique Features

  • Controlled drug release
  • Highly active pharmaceutical ingredient encapsulation
  • High surface area/volume ratio
  • Enhanced mechanical strength
  • Ability to specifically functionalize its surface
  • High nanoporosity

Our Micro/nanoparticles

  • Poly(lactide-co-glycolide acid) (PLGA)
  • Poly(lactide-co-glycolide acid) / polyethylene glycol (PLGA/PEG)
  • Chitosan / tripolyphosphate (CS/TPP)
  • Zeolitic imidazolate framework-8 (ZIF-8)

Our Publications with Our Polymeric Micro/nanoparticles

1. Guler E., Abobakr F. K. M., Taspınar Y. M., Bostan M. S., Eroglu M. S., Cam M. E. Evaluation of the mesalazine-loaded nanoparticles-embedded BSA hydrogels for the ulcerative colitis treatment.
Organic Communications, 2024 (ESCI - Emerging Sources Citation Index, Etki değer: 1.7)

2. Yekeler H. B., Guler E., Beato P. S., Priya S., Abobakr F. K. M., Dogan M., Uner B., Kalaskar D. M., Cam M. E. Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer's disease.
International Journal of Biological Macromolecules, cilt.268, ss.131841, 2024 (SCI-Expanded, Etki değeri: 7.7)

3. Guler E., Yekeler H. B., Parviz G., Aydin S., Asghar A., Dogan M., Ikram F., Kalaskar D. M., Cam M. E. Vitamin B12-loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B12.
International Journal of Biological Macromolecules, cilt.258, ss. 128635, 2024 (SCI-Expanded, Etki değeri: 7.7)

4. Guler E., Cam M. E. The production of curcumin-loaded PLGA/PEG nanoparticle for the treatment of Alzheimer’s disease.
Journal of Research in Pharmacy, cilt.27, 2023 (ESCI - Emerging Sources Citation Index, Etki değeri: 0.6)

5. Cesur S., Cam M. E., Sayin F. S., Gunduz O. Electrically controlled drug release of donepezil and BiFeO3 magnetic nanoparticle-loaded PVA microbubbles/nanoparticles for the treatment of Alzheimer's disease.
Journal of Drug Delivery Science and Technology, cilt.67, ss.102977, 2022 (SCI-Expanded, Etki değeri: 4.5)

6. Hussein M. A. M., Guler E., Rayaman E., Cam M. E., Sahin A., Grinholc M., Mansuroglu D. S., Sahin Y. M., Gunduz O., Muhammed M., El-Sherbiny İ. M. Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
Carbohydrate polymers, cilt.270, ss.118373, 2021 (SCI-Expanded, Etki değeri: 10.7)