We loaded Teucrium polium plant extract, which is one of the endemic plant species and used to reduce blood glucose levels among the public, into nanofiber, one of the nano-sized drug delivery systems, making it suitable for sublingual application and proved its effectiveness in the treatment of diabetes. Our article has been accepted to be published in Journal of Pharmaceutics (Impact value: 3.8) in Elsevier, one of the best publishing houses in the world.We made evaluations as a result of cell culture and animal studies. We supported our results with tests such as ITT and OGTT.